Sure.
Some synergies rely on spells: for example, Curse of Fate is an amazing spell that let you add / subtract 1 to a single roll in each phase.
cast CoF on a Carno that you want to teleport and charge: +1 in the hero phase to the roll of LoSaT, +1 to the charge roll, +1 in the combat phase to score a successful "to wound" and so on.
With dispel at 30", it's harder to cast CoF (or any other spell), AND with the new summoning mechanics, you are not going to field a Slann with Vast Intellect. Or anyway, you are no more using the Slann as a magical machinegun.
We cast less spells, so those synergies are lost.
LoSaT, is a WONDERFUL ability. But when you teleport a unit, you risk to have it outside the range of buffs… for example, the fact that skinks handlers are not part of the unit of Razordons / Sallies, can limit your tactics.
The range of the buff granted by the Astrolith Bearer has been increased but the whole unit must be within said range.
This is good for some small units or single models (shooting basti), BUT makes more difficult for hordes, unless you stick your AB to the back of those 40 warriors. And in that case, it will be a problem to use LoSaT.